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ElectroMotive Drug Administration for Urology
Conventional administration of drugs for urologic pathologies is either by the systemic route or via intravesical instillation and subsequent passive diffusion into the urothelium The well documented concerns with systemic administration are the small quantities of drug locating at the site of disease and side effects which are occasionally severe. The problems associated with conventional intravesical instillation are the slow rate of diffusion across the tightly knit urothelium and a fundamental inability to control the rate of drug administration.
Now, a controllable method for delivery of drugs into the bladder wall
and prostatic urethra has been developed by PHYSION®.
It comprises a noninvasive, painless local drug administration which
provides greater clinical efficacy with higher concentrations of the
drug in the bladder wall than does passive diffusion yet without the
side effects seen with systemic administration.
EMDA® utilises an electrical current to impart an accelerated, directional (towards the tissues) movement of ionized drugs in an intravesical solution, which results in greater quantities of drugs being delivered to greater tissue depths than is achievable by passive diffusion. Furthermore, the rate of drug administration is fully controllable simply by varying the intensity of the electric current.
There is a substantial number of articles on using EMDA for Chemotherapy, for performing TURBT's under a local anaesthetic, cystodistension, UFS treatments, the neurogenic bladder, Peyronie's disease
To receive additional literature about EMDA, please contact Genesis Medical.