Treating Stress Incontinence 
with Urethral Bulking 

For decades particles suspended a in solution have have been injected to cause the narrowing of the urethra or ureter to prevent urine leaking in stress incontinence or reflux from the bladder back up the ureter into the kidneys.

Collagen is used, but because it is resorbed, the effect often lasts for only 6-12 months

A silicone product comprising 200 micron jagged particles in a suspension gel is also used.  However, there have been reports of granuloma formation, autoimmune reactions and malignancy.

Genesis Medical supplies the only urethral bulking material that is natural to the body and which provides a totally safe tissue augmentation. Many believe this product, Coaptite, will soon become the most widely used material for treating both Stress Incontinence.

This material, calcium hydroxylapatite, has a long history as an implant material and as it is a synthetic form of the major component of bone, it is tissue friendly 

Coaptite carries a CE mark and is approved by the FDA.
In the USA and Canada Coaptite is distributed by Boston Scientific and they provide useful information on their website 
 

BROCHURE

 Coaptite comprises smooth 100 micron spheres of synthetic calcium hydroxylapatite suspended in a mainly glycerine and water gel with a chemically-modified naturally occuring polysaccharide sodium carboxymethylcellulose as support.

CaHA is natural to the body and is inert in soft tissue. Neither the CaHA nor the gel cause tissue reaction or inflammation. There is no burning sensation when Coaptite is injected. The smooth 100 micron spheres are densely distributed in the gel so less material is needed for bulking.

 

The patented carrier gel remains in situ until tissue grows in to take its place. Healthy tissue grows through the deposit and against the particles to form a tissue and Coaptite matrix which remains soft and pliable.

The deposit remains localised and stationary within the injection site. There is no migration nor resorption.

Soft and pliable tissue and Coaptite explant                    
after 12 months

 The three slides are from a dog bladder explanted 12 months after Coaptite injection.


Coaptite™. ......The only solution to combine so many benefits.

• Neither Coaptite nor the carrier gel cause tissue reaction and no inflammation occurs.
• No capsule is formed.
• Healthy tissue grows without change against and through the smooth CaHA spheres to form a soft and pliable tissue and Coaptite matrix.
• There is no migration and no resorption.
• The 100 micron spheres are smooth and densely packed in the carrier gel so that on average only 2.5ml of material is needed for stress incontinence.
• Coaptite flows smoothly through the 21 guage needle with finger pressure control.
• Five year results are excellent. Patients dry after the procedure are still dry after 5 years.
• Radiopaque
• No sensitivity testing required. No special storage required.

Needle size: 21 guage         
Average quantity required for Stress Incontinence: 2.5 cc or 3x 1cc syringes.

GSI:   Pretreatment mean 24-hr Pad weight: 104.87gm, and at 12
          months: 1.46gm.¹

          5 year follow-up data shows 12 and 37 month results persisting.
Please contact Genesis Medical for the Clinical papers

 
1.Preliminary Evaluation of Calcium Hydroxylapatite as a Transurethral Bulking Agent for Stress Urinary Incontinence. Robert Mayer et al UROLOGY 57 (3), 2001